Enrolled individuals had been also required to perform a minimum of 5 night time shifts per month, have too much sleepiness at enough time of their night shifts (MSLT rating < six minutes), and also have daytime insomnia documented by a daytime polysomnogram.

Significant rash requiring hospitalization and discontinuation of cure has actually been documented in association with the usage of modafinil.

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An overdose of modafinil can cause A variety of indications and problems. Psychiatric indicators may perhaps involve psychosis, mania, hallucinations, and suicidal ideation, which could arise even in individuals without having a record of psychological illness and should persist immediately after discontinuation on the drug.

Modafinil isn't a direct- or oblique-acting dopamine receptor agonist. Having said that, in vitro, modafinil binds on the dopamine transporter and inhibits dopamine reuptake. This activity has actually been related in vivo with amplified extracellular dopamine amounts in certain brain locations of animals.

Stimulants like modafinil Use a low likely for abuse and dependancy. It's really a “Timetable IV drug,” a designation the more info Drug Enforcement Agency employs for prescription drugs which has a reduced potential for abuse.

The mechanism(s) by which modafinil encourages wakefulness is unidentified. Modafinil has wakepromoting actions much like sympathomimetic brokers together with amphetamine and methylphenidate, although the pharmacologic profile isn't identical to that in the sympathomimetic amines.

Significant rash necessitating hospitalization and discontinuation of procedure has been reported in Affiliation with using modafinil.

Quit using PROVIGIL and simply call your doctor straight away or get emergency assist For those who have any of those signs or symptoms:

When this medication is applied for years, it might not perform in addition. Speak with your medical professional if this medication stops Doing work very well.

Will not flush drugs down the toilet or pour them right into a drain unless instructed to take action. Effectively discard this product when it can be expired or not desired. Talk to your pharmacist or local squander disposal firm.

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Choose PROVIGIL exactly as prescribed by your medical doctor. Your medical professional will prescribe the dose of PROVIGIL that is definitely right for you. Don't alter your dose of PROVIGIL without having conversing with your doctor.

Individuals taken care of with PROVIGIL confirmed a statistically important prolongation in the time to rest onset when compared to placebo-addressed patients, as calculated with the nighttime MSLT at final visit (Table 2).